Distinguish between smooth endoplasmic reticulum and rough endoplasmic reticulum.

Rough endoplasmic reticulum has ribosomes attached to its surface. Rough endoplasmic reticulum has ribosomes attached to its surface. Smooth endoplasmic reticulum has ribosomes attached to its surface. Smooth endoplasmic reticulum has ribosomes attached to its surface. Rough endoplasmic reticulum has vacuoles attached to its surface. Rough endoplasmic reticulum has vacuoles attached to its surface. Smooth endoplasmic reticulum has vacuoles attached to its surface.

I'm sorry, but there seems to be repetition in the information provided. I'll correct and explain the differences between smooth endoplasmic reticulum (SER) and rough endoplasmic reticulum (RER) for better clarity:

1. Presence of ribosomes: Rough endoplasmic reticulum (RER) has ribosomes attached to its surface, giving it a "rough" appearance. This ribosome attachment is absent in smooth endoplasmic reticulum (SER).

2. Protein synthesis: RER is involved in the synthesis and modification of proteins due to the presence of ribosomes. These ribosomes help in translating the genetic information from the DNA into proteins. In contrast, SER is mainly responsible for lipid metabolism, detoxification, and the storage and release of calcium ions.

3. Internal structure: Both RER and SER consist of interconnected tubules and cisternae (flattened sacs). However, RER has a more extensive and complex system due to the presence of ribosomes.

4. Cellular function: RER plays a crucial role in protein synthesis, folding, and packaging of proteins before they are transported to their final destinations, such as the Golgi apparatus. SER, on the other hand, has various functions including lipid synthesis, detoxification of drugs and toxins, and regulation of calcium levels within the cell.

5. Location: RER is commonly found near the nucleus, whereas SER is distributed throughout the cytoplasm, often surrounding the nucleus and extending into other parts of the cell.

In summary, the main distinction between RER and SER lies in the presence of ribosomes and their respective functions.