Charmaine is mailing packages. Each small package costs her $2.10 to send. Each large package costs her $3.60 . How much will it cost her to send 1 small package and 5 large packages?

The cost of sending 5 large packages is 5 * $3.60 = $<<5*3.6=18>>18.

The cost of sending 1 small package is $2.10.
So, it will cost Charmaine $18 + $2.10 = $<<18+2.1=20.10>>20.10 to send 1 small package and 5 large packages. Answer: \boxed{20.10}.