Which of the following are mechanisms that bacteria use for antibiotic resistance? (select all that apply):

A. Block/decrease entry of the drug into the cell
B. trap the drug in vescicles within the bacterial cell
C. use an alternative metabolic/enzymatic pathway than is targeted by the drug
D. pump the drug out of the cell
E. destroy/cleave the drug

A. Block/decrease entry of the drug into the cell

C. use an alternative metabolic/enzymatic pathway than is targeted by the drug
D. pump the drug out of the cell
E. destroy/cleave the drug