Analyze the timeline to indicate how antisemitism grew in Europe during the 1500s.

both catholic and protestant leaders made life difficult for European Jews

the growth of antisemitism was limited to catholic nations in Southern Europe

the growth of antisemitism was limited to Protestant nations in Northern Europe

Both Catholic and Protestant leaders were able to improve relations with European Jews by the end of the 1500s

Based on the given information, it seems that the growth of antisemitism during the 1500s was not limited to any specific religious group or region in Europe. Both Catholic and Protestant leaders were responsible for making life difficult for European Jews during this time. Therefore, it can be concluded that antisemitism spread across the entire continent during the 1500s, affecting both Catholic and Protestant nations.