In the early 1600s, which issue regarding contact between the Europeans and the Japanese was a primary area of concern for the Tokugawa regime? (1) Europeans might interfere in Japan’s cultural traditions. (2)Japanese jobs were taken by European workers. (3) Japanese exports were not competitive in European markets. (4) Europeans could gain control of Japan’s coal mines.

The primary area of concern for the Tokugawa regime regarding contact between the Europeans and the Japanese in the early 1600s was (1) Europeans might interfere in Japan's cultural traditions.