There are four performers who will present their comedy acts this weekend at a comedy club. How many different ways are there to schedule their appearances?

To calculate the number of different ways to schedule the appearances of the four performers, we need to find the number of possible permutations.

The number of permutations of four performers can be found using the factorial function, denoted by "!". The formula is:

4! = 4 × 3 × 2 × 1 = 24.

Therefore, there are 24 different ways to schedule the appearances of the four performers at the comedy club this weekend.