A bakery sold 3.5 dozen cupcakes in the morning and 2.25 dozen cupcakes in the afternoon. If each dozen of cupcakes costs $12, how much money did the bakery make from selling cupcakes that day?

The bakery sold a total of 3.5 + 2.25 = <<3.5+2.25=5.75>>5.75 dozens of cupcakes

Therefore, the bakery made a total of 5.75 x $12 = $<<5.75*12=69>>69 from selling cupcakes that day. Answer: \boxed{69}.