A sheet of paper 11 inches tall and 8 1/2 inches wide has 1-inch margins at the top and bottom and 3/4 -inch margins at each side. If nothing is to be printed in the margins, what is the area of the printable region?

The width of the printable region is $8\frac{1}{2}-2\cdot\frac{3}{4}=7$ inches. The height of the printable region is $11-2=9$ inches. Therefore, the area of the printable region is $7\times9=\boxed{63}$ square inches.