Which of the following explains the impact of the creation of the smallpox vaccine on the Americas?

A. It prevented milkmaid on the two continents from getting the disease
B. It led to the development of ways to prevent the disease like mosquito nets
C. It led to the deaths of about 90 percent of Indigenous Americans
D. It led to the complete eradication of the disease.

C. It led to the deaths of about 90 percent of Indigenous Americans