Yes, healing by second intention does involve wound contraction aided by myofibroblasts. In this type of wound healing, the wound edges are not brought together, and the wound heals from the bottom up, gradually filling in with granulation tissue and contracting over time. Myofibroblasts are specialized cells that are responsible for wound contraction. These cells have characteristics of both fibroblasts and smooth muscle cells, allowing them to generate mechanical forces to pull the wound edges closer together. This process helps reduce the size of the wound and promote healing.
