The gold standard for pathologic diagnosis is the examination of tissue samples (biopsies or surgical specimens) under a microscope by a pathologist. This involves the preparation of the tissue samples through fixation, processing, sectioning, and staining, followed by examination and interpretation of the cellular and tissue features using light microscopy. This process allows the pathologist to identify any abnormal or diseased changes in the tissue, classify the disease or condition, and provide a definitive diagnosis. The pathologic diagnosis is considered the most accurate and reliable method for identifying and characterizing various diseases and conditions.
