One fragment of complement that is important for chemotaxis is the C5a fragment. C5a is released during the activation of the complement system and acts as a chemoattractant for immune cells. It attracts neutrophils and other immune cells to the site of infection or injury, promoting the inflammatory response and enhancing the immune system's ability to eliminate pathogens. C5a binds to specific receptors on immune cells, activating intracellular signaling pathways that lead to cytoskeletal rearrangement and cell migration towards the C5a source. This fragment of complement is crucial for the recruitment and direction of immune cells during the process of chemotaxis.
