Desiree is making guacamole for a party. The recipe she is using calls for 1/4 cup of lime juice for every 4 cups of avacados. If she plans to use 1 cup of lime juice, how many avacados does she need?

If 1/4 cup of lime juice is used for every 4 cups of avocados, then 1 cup of lime juice is used for every 4*4 = <<1/4*16=4>>16 cups of avocados.

If 1 cup of lime juice is used for every 16 cups of avocados, then for 1 cup of lime juice, Desiree needs 16 avocados. Answer: \boxed{16}.