Gas chromatography

Gas chromatography is a technique used to separate and analyze components of complex mixtures based on their chemical and physical properties. It involves the injection of a sample into a gas chromatograph, which is equipped with a stationary phase (a chromatography column) and a mobile phase (a carrier gas).

The mobile phase carries the sample through the chromatography column, where the analytes interact with the stationary phase. The stationary phase is typically a thin film coated on the inside surface of the column. As the sample moves through the column, the different components interact with the stationary phase to varying degrees, resulting in separation based on their affinity for the stationary phase.

The separated components exit the column and enter a detector, which measures the amount of each component present. Common detectors used in gas chromatography include flame ionization detectors (FID), thermal conductivity detectors (TCD), and mass spectrometers (MS).

Gas chromatography is commonly used in analytical chemistry and the pharmaceutical, food, and environmental industries to identify and quantify compounds present in samples. It is a highly sensitive and accurate technique, capable of separating and detecting even trace amounts of analytes in a mixture.