The two countries in North America that have established the largest trading partnership are Canada and the United States.
The correct answer is Canada and Mexico. To get to this answer, you can use general knowledge or conduct a quick research. North America consists of three countries: Canada, Mexico, and the United States. When looking at trading partnerships, the two countries that have the largest and most well-established trading relationship are Canada and Mexico. The United States also has significant trade relationships with both Canada and Mexico, but the largest partnership is between Canada and Mexico.