______________ IS an ancient region of southwest Asia between the Tigris and Euphrates rivers.

Egypt
Saudi Arabia
Sudan
Mesopotamia

Mesopotamia

The correct answer is Mesopotamia.

To arrive at this answer, one should be familiar with the geography and history of ancient southwest Asia. The region referred to as Mesopotamia is located between the Tigris and Euphrates rivers, which flow through modern-day Iraq. It is often considered one of the cradles of civilization and was home to several of the world's earliest civilizations, including the Sumerians, Akkadians, Babylonians, and Assyrians.

To verify this information, one can refer to historical sources, encyclopedias, or textbooks that provide details about the ancient civilizations and geography of the region. Additionally, a simple internet search using the keywords "ancient region between Tigris and Euphrates rivers" would also provide the correct answer.

Mesopotamia