In which of the following areas is there a large concentration of American and First Nations peoples?

A. The interior west of the United States and Canada
B. The Atlantic and Pacific coast of the United States and Canada
C. The Great Lakes region of the United States and Canada
D. The Atlantic coast of the United States and Canada

C. The Great Lakes region of the United States and Canada

The option with a large concentration of American and First Nations peoples is B. The Atlantic and Pacific coast of the United States and Canada.

To determine the correct answer, we need to consider the historical and geographical factors that determine the concentration of American and First Nations peoples in different areas.

A. The interior west of the United States and Canada: Historically, the interior west of the United States and Canada had a lower concentration of American and First Nations peoples compared to other areas. This region was largely inhabited by other indigenous groups, such as the Plains Indians in the US and the First Nations groups in Canada.

B. The Atlantic and Pacific coast of the United States and Canada: The Atlantic and Pacific coast of the United States and Canada have historically had a larger concentration of American and First Nations peoples. This is due to the proximity to waterways, which provided access to resources and trade opportunities. Additionally, these coastal regions were often the first areas colonized by Europeans, resulting in a higher concentration of indigenous populations.

C. The Great Lakes region of the United States and Canada: The Great Lakes region has also had a significant concentration of American and First Nations peoples. This is because the Great Lakes served as important trade routes and provided access to abundant resources. Additionally, this region has historically been a meeting point of different tribes and nations, resulting in a diverse indigenous population.

D. The Atlantic coast of the United States and Canada: Similar to the Pacific coast, the Atlantic coast has also had a large concentration of American and First Nations peoples. This is due to its proximity to waterways, access to resources, and early European colonization.

Based on the above analysis, the correct answer is B. The Atlantic and Pacific coast of the United States and Canada.