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The attached figure is a schematic of the ventricular-subventricular zone (V-SVZ) stem cell niche of the brain and its regulation. Multiciliated ependymal cells (E; light gray) line the ventricle and contact the apical surface of V-SVZ neural stem cells (NSCs, blue). Typically quiescent B1-type NSCs (dark blue) give rise to activated B2 and B3 cells (lighter shades of blue) that possess limited proliferation. The B3 cells generate the C cells (green), which, after three rounds of division, give rise to migrating neuroblasts (A cells; orange). The niche is penetrated by endothelial cell-built blood vessels that are in part enwrapped by the basal endfeet of B cells. Maintenance of the stem cell pool is regulated by VCAM1 adhesion and Notch signaling (changes in Notch pathway oscillations are depicted as color changes in the nuclei). Clusters of neurons in the ventral region of the lateral ventricle express Sonic hedgehog (Shh) that influence different neuronal cell differentiation from the niche. Antagonistic signaling between BMP and Noggin from endothelial cells and ependymal cells, respectively, balance neurogenesis along this gradient. Serotonergic (5HT) axons lace the ventricular surface , and—along with IL1-β and GDF11 from the cerebral spinal fluid (CSF) and blood, respectively—play roles as external stimuli to regulate the niche. Non-niche neurons, astrocytes, and glia can be found within the niche and influence its regulations. Glial fibrillary acidic protein (GFAP); brain lipid binding protein

(BLBP); double cortin (DCX).
Which neural stem cells of the V/SVZ niche have an apical process that contacts the cerebrospinal fluid?

The neural stem cells of the V-SVZ niche that have an apical process that contacts the cerebrospinal fluid are the multiciliated ependymal cells (E; light gray).

The neural stem cells (NSCs) of the V/SVZ niche that have an apical process that contacts the cerebrospinal fluid are the B1-type NSCs (dark blue). These B1-type NSCs have an apical surface that comes into contact with the cerebrospinal fluid.

The neural stem cells in the V-SVZ niche that have an apical process that contacts the cerebrospinal fluid (CSF) are the multiciliated ependymal cells (E), which line the ventricle and make direct contact with the CSF. These multiciliated ependymal cells have light gray color in the schematic figure. They have numerous hair-like structures called cilia on their apical surface, which extend into the CSF and allow them to come into direct contact with it. These ependymal cells play a role in regulating the V-SVZ neural stem cell niche by providing physical and molecular support to the stem cells.