The main, or central, idea of the passage is Minot's liver cure experiment led to the discovery that a condition called pernicious anemia involves the inability to absorb vitamin B₁₂. How does the detail in bold develop the main idea?

In the 1920s, George Minot was searching for a cure for pernicious anemia, a then-fatal disease characterized by the body's inability to produce enough red blood cells. Minot began experimenting with feeding large amounts of beef liver to his patients—up to half a pound per day. Incredibly, the diet produced marked improvements. Why the medical miracle? As revealed by later research, liver contains high levels of vitamin B₁₂, which is essential for the production of red blood cells. People with pernicious anemia lack a glycoprotein called intrinsic factor, which helps the body absorb vitamin B₁₂ in the small intestine. As a result, their red blood cell numbers drop. Because Minot's patients could absorb only a tiny percentage of the vitamin B₁₂ in their food, they had to ingest large amounts of liver in order to survive. Today, people with pernicious anemia are prescribed B₁₂ injections so that they no longer have to rely on the "liver cure."

The detail in bold develops the main idea by explaining the connection between Minot's liver cure experiment and the discovery about pernicious anemia. It reveals that Minot's patients saw improvements because liver contains high levels of vitamin B₁₂, which is essential for the production of red blood cells. This detail highlights the role of vitamin B₁₂ in treating pernicious anemia and explains why Minot's experiment was successful.

The detail in bold, "People with pernicious anemia lack a glycoprotein called intrinsic factor, which helps the body absorb vitamin B₁₂ in the small intestine," develops the main idea of the passage by explaining why Minot's liver cure experiment was successful. It shows that the reason for the improvement in his patients was that the beef liver he fed them contained high levels of vitamin B₁₂, which they were unable to absorb properly due to their lack of intrinsic factor. This detail directly connects the experiment to the discovery about pernicious anemia involving the inability to absorb vitamin B₁₂.