Review the diagram, below - which letter represents the substrate?

a
A
b
B
c
C
d
D

It is not possible to accurately review the diagram without actually seeing the diagram.

In order to identify which letter represents the substrate in the given diagram, let's first understand what a substrate is. In the context of biochemistry and enzymology, a substrate refers to the molecule upon which an enzyme acts.

Looking at the diagram, we see four letters labeled: A, B, C, and D. To determine the substrate, we need to identify the molecule that the enzyme is acting upon.

Unfortunately, without additional information or context provided, it is not possible to determine which letter represents the substrate in this diagram.