What is the greatest determinant of the intracellular water volume?

A)Na^ +
B) PO 4 ^ 3-
C)Cl^-
D) Ca^ 2+
E)K^ +

E) K+

The greatest determinant of the intracellular water volume is the concentration of solutes, particularly ions, in the intracellular fluid. This concentration gradient drives the movement of water across the cell membrane through processes like osmosis.

Among the options provided, the most significant ion influencing intracellular water volume is probably Na+ (sodium ion). Sodium plays a crucial role in maintaining osmotic balance and regulating cellular hydration. By controlling the movement of sodium ions, cells are able to regulate the movement of water in and out of the cell, thus impacting intracellular water volume.

Therefore, the correct answer is A) Na+.