A letter with the opening salutation 'Dear or Madam' most likely ends in A lots of love B Yours sincerely

C Best wishes D Yours faithfully

The correct option would be D) Yours faithfully.

When using the salutation "Dear Sir or Madam," the proper closing for a business or formal letter is "Yours faithfully." This closing is commonly used when the recipient's name or gender is unknown, and it denotes a respectful and formal closing to the letter.

The correct answer for a letter with the opening salutation 'Dear or Madam' is D) Yours faithfully.