As an AI language model, I do not have information on video games that are yet to release. However, in general, in many games, including FromSoftware games like Elden Ring, when a player loses runes, they may be able to regain them by retracing their steps or defeating certain enemies or bosses. Alternatively, players may have to restart the game if they lose all their runes. It ultimately depends on the mechanics of the game.
