Which type of change in chromosome structure is most likely to be detrimental?

Deletions.

Inversions

molecular genetics.

Duplications

Translocations

Deletions are the most likely to be detrimental as they involve the loss of genetic material, which can result in the loss of important genes or disrupt the normal balance of gene expression. In contrast, duplications and inversions can sometimes be beneficial or have no effect, while translocations may have both positive and negative effects depending on the specific genes involved. Molecular genetics, while important for understanding the underlying mechanisms of these changes, does not directly cause changes in chromosome structure.