if p=2, q=-3 and r=4 calculate 25r + 12q/(pr) raise to power two

Substitute p=2, q=-3 and r=4 into the expression:

25r + 12q/(pr)
= 25(4) + 12(-3)/(2(4)) // simplify the numerator and denominator separately
= 100 - 9/4
= 399/4

Then raise the result to the power of two:

(399/4)^2
= 159201/16

Therefore, 25r + 12q/(pr) raised to power two, when p=2, q=-3 and r=4, is equal to 159201/16.