3/8 of the can drinks in a box were Lemon Fizz and the rest were Orange Fizz. Joy took 18 cans of the Lemon Fizz from the box. Crystal took 3/4 of the cans of Orange Fizz from the box. After that, 1/4 of the can drinks remained in the box. How many can drink were removed from the box by Joy and Crystal?

18 * (4/3) = 24

24 + 18 = 42
24 * (1/4) = 6
42 + 6 = 48 can drinks were removed

If there were x cans of fizz, then

lemon = 3/8 x
orange = 5/8 x
x - 18 - (3/4)(5/8 x) = 1/4 x
x = 64
check:
3/8 * 64 = 24
64 - 18 - (3/4)*40 = 64-18-30 = 16
16 = 1/4 of 64