1. How do you go to school? By bus?

Nio, I go there by subway.

2. What do you take to school? By bus?
Nio, I go there by subway.
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Is #1 the same as #2? Can we use 'What do you take to school?' instead of 'How do you go to school?'

1 is correct. 2 should be "The bus?" "What" is the subject of the first sentence. What is referring to something, in this case THE bus or THE subway. The sentence, "No, I go there by subway" is correct.

And it's "no," not "nio."

1. How do you go to school? By bus?

No, I go there by subway.

2. What do you take to school? The bus?
No, I go there by subway.

3. What do you take to school? A bus?
No, I go there by subway.

4. What do you take to school? Buses?
No, I go there by subway.

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Thank you for your help. Do you mean #2 is correct? What about the other expressions?

Yes, now #2 is correct. The others are also correct. :)

No, #1 and #2 are not the same.

In #1, the question is specifically asking about the method of transportation to school. It is asking "How do you go to school?" which implies asking about the mode of transportation, such as by bus, subway, or any other means. The answer given, "By subway," indicates that the person goes to school using the subway.

In #2, the question is asking what items or things the person takes with them to school, not about the mode of transportation. The question "What do you take to school?" implies asking about the belongings or items one carries with them to school, like books, backpack, or lunch. The answer to this question would be different and unrelated to the mode of transportation.

So, in short, "How do you go to school?" and "What do you take to school?" have different meanings and cannot be used interchangeably.