A perfect minor wholetone is a frequency rtio of 10:9.

A perfect major wholetone is a frequency ratio of 9:8.
Are these noticeably different from an equal temper wholetone? (200 cents)

They are certainly different from each other.

They also differ from the equivalent equitempered pairs, where the frequency ratio of successive chromatic-scale notes is 2^(1/12) = 1.059