human risk assessment

David Hassenzahl discusses the relative risks of eating peanut butter contaminated with aflatoxin and apple juice contaminated with UDMH, a degradation product of Alar, in the Power Point presentation in the Week Five, Module 5 Conference. The following Table shows his input data.

Variable Units Average 5th %ile 95th %ile Distribution
Peanut butter intake g/day 11.38 2.00 31.86 Lognormal
Apple juice intake g/day 136.84 16.02 430.02 Lognormal
Aflatoxin concentration ug/kg 2.82 1.00 6.5 Lognormal
UDMH concentration ug/kg 13.75 0.5 42.00 Lognormal
Aflatoxin potency kg-day/mg 17.5 4.02 28.33 Normal
UDMH potency kg-day/mg 0.49 0.00 0.85 Normal

a. Calculate the daily cancer risk for a child who weighs 20 kg and who eats an average amount of peanut butter
b. Do the same for a 20 kg child who drinks an average amount of apple juice.

NOTE: Daily cancer risk = Intake x Concentration x Potency / Body Weight

c. Calculate the maximum daily cancer risks for peanut butter and apple juice based on the 95th percentiles.

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  1. The Table does not appear in your post.

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  2. Variable Units Average 5th %ile 95th %ile Distribution
    Peanut butter intake g/day 11.38 2.00 31.86 Lognormal
    Apple juice intake g/day 136.84 16.02 430.02 Lognormal
    Aflatoxin concentration ug/kg 2.82 1.00 6.5 Lognormal
    UDMH concentration ug/kg 13.75 0.5 42.00 Lognormal
    Aflatoxin potency kg-day/mg 17.5 4.02 28.33 Normal
    UDMH potency kg-day/mg 0.49 0.00 0.85 Normal

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  3. What are the advantages and disadvantages of animal studies and epidemiological studies for establishing dose-response relationships?

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