Which human organ system is the first to become visibly differentiated during development? Which is the second? What is the significance of this order?

Embryology is the topic area you desire. Since this is not my area of expertise, I searched Google under the key words "embryology 'organ systems' development" to get these possible sources:

(Broken Link Removed)
http://www.niaaa.nih.gov/Resources/GraphicsGallery/FetalAlcoholSyndrome/Embryonic.htm
http://en.wikipedia.org/wiki/Embryology
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http://missinglink.ucsf.edu/lm/IDS_101_embryology_basics/CoreText.htm

In the future, you can find the information you desire more quickly, if you use appropriate key words to do your own search.

I hope this helps. Thanks for asking.

The first human organ system to become visibly differentiated during development is the cardiovascular system, specifically the development of the heart. The second organ system to become visibly differentiated is the nervous system, which includes the brain and spinal cord.

The significance of this order lies in the essential functions performed by these systems. The cardiovascular system, particularly the heart, is crucial for supplying oxygen and nutrients to developing tissues and organs. By early embryonic stages, blood vessels begin to form, which eventually give rise to the heart structure. The early development of the heart ensures the circulation of blood, allowing other organs to receive the necessary materials for growth and development.

The subsequent differentiation of the nervous system is also vital. The nervous system plays a central role in coordinating and controlling various bodily functions. The early development of the brain and spinal cord allows for the establishment of neural connections and the specialization of different regions responsible for processing sensory information, controlling movement, and regulating bodily functions.

Overall, the order of cardiovascular system differentiation followed by the nervous system signifies the importance of ensuring an adequate supply of nutrients and oxygen to support the developing organs, as well as the establishment of the complex neural network necessary for coordinating and controlling bodily functions.