We as humans make terrible blunder

Does this make sense?

Yes, but it is not good grammar. It would be better if it said, "We, as humans make a terrible blunder." if you mean a particular blunder or mistake. If you mean many mistakes, you would write, "We, as humans, make terrible blunders." Note the commas that set off the adjective phrase.

Sorry, typo. "We, as humans, make..."

Yes, the statement "We as humans make terrible blunders" makes sense. It suggests that as human beings, we sometimes make serious or careless mistakes. This statement reflects a general observation about human fallibility.

If you're referring to the grammatical structure of the sentence, it is a declarative statement in which the subject (we as humans) performs an action (make terrible blunders). It follows the subject-verb-object construction commonly used in English sentences.