How many grams of AlNO3 could be used to make the following prescription isotonic?
Sol.Silver Nitrate 2.5%
Sodium chloride q.s.
Sterile water for injection
There is only anhydrous dextrose 5% available
I have calculated 4.5g of NaCl should be used. Is it correct?
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To determine the number of grams of AlNO3 needed to make the given prescription isotonic, we need to follow a step-by-step approach:
Step 1: Understand the concept of isotonicity
Isotonicity refers to a solution having the same osmotic pressure as another solution or cell. In the context of pharmaceutical preparations, an isotonic solution is formulated to have the same osmolarity as blood plasma, which prevents discomfort and damage when injected.
Step 2: Gather information about the prescription
The prescription you provided consists of Sol. Silver Nitrate 2.5%, Sodium chloride q.s. (quantum satis, enough to), and sterile water for injection. However, there is only anhydrous dextrose 5% available.
Step 3: Determine the composition of an isotonic solution
To make the solution isotonic, we need to add an appropriate amount of solute, in this case, AlNO3, to the given prescription. An isotonic solution should have an osmolarity close to that of blood plasma, which is approximately 0.9%.
Step 4: Calculate the osmolarity of the prescription
To calculate the osmolarity, we need to consider the contributions of each component in the prescription. Since only the percentage concentration of Sol. Silver Nitrate 2.5% is provided, we'll assume that the other components do not contribute significantly to the osmolarity.
From the given information, it's unclear what the concentration of AlNO3 should be in the prescription. Therefore, we cannot directly calculate the amount of AlNO3 required to make an isotonic solution.
Step 5: Discuss with a pharmacist or consult reliable references
To accurately calculate the amount of AlNO3 needed, it's recommended to discuss this with a pharmacist or consult other reliable references, such as pharmacology textbooks or pharmaceutical guidelines.
These sources will provide the necessary information about AlNO3 concentration limits and formulations for isotonic solutions. They will guide you in determining the appropriate amount of AlNO3 that can be safely used to achieve isotonicity in the given prescription.
Remember, pharmaceutical calculations require precise knowledge and should always be performed with the guidance of a qualified professional to ensure patient safety.