Pharmacology

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You provide the manufacturer’s recommended dose of an antibiotic, which is 10mg/kg IV for a 100kg patient. You then draw a level 30 minutes after the dose. Assume rapid distribution and neglible clearance/metabolism over the 30minute period between the time of administration and drug level assement.

3. The serum level of this antibiotic returns at 83.3mg/L. What is the volume of distribution of the drug?
A. 1.6 Liters

B. 16 Liters

C. 12 Liters

D. 1.2 Liters

E. 8 Liters


4. Assume the goal therapeutic serum level of a is 120 mg/L. How much more drug do you need to order to attain this level.

A. 60mg

B. 300mg

C. 45 mg

D. 450mg

E. 600mg

5. A patient with chronic kidney disease has a vancomycin serum level drawn that returns at 37mcg/mL. She will require a redose when the level reaches 15mcg/mL. Her half-life has been determined to be 46 hours. How many hours after the initial serum draw will she require a redose.

A. 52 hours

B. 60 hours

C. 67 hours

D. 73 hours

E. 80 hours

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