why is lupus inhibitors important
Lupus inhibitors, also known as lupus anticoagulants, are antibodies that can interfere with the normal clotting of blood in a laboratory setting. Despite the name, lupus inhibitors are not specific to individuals with lupus, as they can be found in people without the autoimmune disease as well. However, they are associated with several important medical conditions, including autoimmune disorders, such as systemic lupus erythematosus (SLE), and an increased risk of blood clotting.
Lupus inhibitors are important for a few reasons:
1. Diagnosis of lupus: The presence of lupus inhibitors is one of the diagnostic criteria for systemic lupus erythematosus (SLE). When certain clinical symptoms are present, along with the presence of lupus inhibitors and other specific laboratory findings, it can help confirm the diagnosis of SLE.
2. Increased risk of blood clotting: Lupus inhibitors can lead to an increased risk of abnormal blood clotting, known as thrombosis. This can manifest as deep vein thrombosis (DVT), pulmonary embolism, strokes, and other clotting disorders. Identifying the presence of lupus inhibitors can help healthcare providers identify individuals who may be at a higher risk of developing blood clots and take necessary preventive measures.
3. Monitoring anticoagulant therapy: Lupus inhibitors can interfere with the results of certain clotting tests used to monitor anticoagulant (blood-thinning) therapy, such as warfarin. It is essential to identify the presence of lupus inhibitors in these cases to ensure accurate monitoring of anticoagulant therapy and prevent complications.
To determine the presence of lupus inhibitors, laboratory tests such as the activated partial thromboplastin time (APTT) and dilute Russell's viper venom time (dRVVT) are performed. If these tests suggest the presence of lupus inhibitors, further confirmatory tests may be conducted to establish a definitive diagnosis.
It is crucial to note that the interpretation of lupus inhibitors' results and their clinical implications can be complex. Therefore, it is best to consult with a healthcare professional or a rheumatologist who specializes in autoimmune disorders for accurate interpretation and appropriate management.