Human Biology-Birth Defects

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Hey I'm doing a report on clubfoot and I just researched this about it:

"Complex segregation analyses suggest that
the most likely inheritance pattern is a single gene of
major effect, operating against a polygenic background."

what does it mean by "operating against a polygenetic background"?

Thanks!

  • Human Biology-Birth Defects -

    A polygenic background means that several genes may be responsible for a specific condition.

    Check this definition.

    http://dictionary.reference.com/browse/polygenic

  • Human Biology-Birth Defects -

    I understand that, but how can it say that one gene is operating against a whole bunch of genes?

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