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In human body, enzymes are used as a catalyst in reactions. Why the rate of reaction would decrease above 37 degree celcius in human body?

Enzymes serve as catalysts because of their shape and/or structure. They are usually quite specific for a particular process in the human body. The shape is sensitive to temperature. If the shape changes the enzyme may not be able to carry out its particular function. Secondly, if the temperature rises enough, the protein part of the enzyme may be degraded. In summary, increases in temperature may affect the shape or be involved in degradation of the enzyme. I hope this helps.

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