which of these scenarios model how mutations can be detrimental to an organism

1) A mutation occurs in a gene responsible for producing an essential enzyme, leading to the enzyme being non-functional. This results in the organism being unable to metabolize a necessary substance, ultimately leading to its death.

2) A mutation causes a structural change in a protein that is crucial for proper cell division. As a result, the mutated cells divide uncontrollably, leading to the development of cancer in the organism.

3) A mutation disrupts the regulatory region of a gene involved in controlling the expression of other genes. This results in incorrect levels of gene expression, leading to abnormal development and functioning of the organism.