Mutations can be beneficial neutral or harmful in an organism changing their fitness in a population which of these scenarios model how mutations can be detrimental to an organism
1. A harmful mutation causes a change in the protein structure of an essential enzyme, resulting in a loss of its function and the inability of the organism to properly digest nutrients.
2. A harmful mutation leads to a structural change in a key regulatory gene, causing abnormal growth and development in the organism.
3. A harmful mutation results in a loss of function in a gene responsible for repairing DNA damage, leading to increased susceptibility to cancer and other diseases.
4. A harmful mutation causes an alteration in a receptor protein on the cell surface, disrupting the organism's ability to respond to important signals from its environment.