Mutations can be beneficial m, neutral, or harmful in an organism changing their fitness in a population. Which of these scenarios model how mutations can be detrimental to an organism

1. A mutation that causes a loss of function in a critical gene, leading to a decreased ability to survive and reproduce.

2. A mutation that results in a structural change in a protein, rendering it non-functional and disrupting important cellular processes.

3. A mutation that increases the susceptibility of an organism to certain diseases or environmental stressors, decreasing its chances of survival in its natural habitat.