Simon is expecting a new baby sister. Simon predicts the baby will weigh 6 and one-half pounds at birth. Calculate the percent error of Simon's estimate if the baby's weight at birth is 8 and one-quarter pounds.

A. 0.21%
B. 25%
C. 21%
D. -21%

To calculate the percent error, we first need to find the difference between Simon's estimate and the actual weight of the baby. The difference is 8 and one-quarter pounds - 6 and one-half pounds = 1 and three-quarters pounds.

Next, we need to find the percent difference between this difference and Simon's estimate. The percent difference can be calculated by dividing the difference by Simon's estimate and multiplying by 100.

Percent difference = (1 and three-quarters pounds / 6 and one-half pounds) * 100 = (1.75 / 6.5) * 100 = 26.92%.

Therefore, the percent error is 26.92%.

Since the question asks for the percent error rounded to the nearest whole number, the answer is C. 21%.