why hcg is higher in complete mole than partial mole?
Human chorionic gonadotropin (hCG) levels are higher in complete moles compared to partial moles because complete moles are usually associated with the abnormal fertilization of an egg that lacks genetic material. This results in the complete mole having cells with two sets of paternal chromosomes and no maternal chromosomes.
Because there is no normal embryonic tissue in a complete mole, the trophoblastic cells (which secrete hCG) proliferate rapidly in an attempt to support the "pregnancy." This leads to significantly higher levels of hCG being produced in complete moles compared to partial moles, where there is some normal embryonic tissue present.
In contrast, partial moles typically occur when a normal egg is fertilized by two sperm, resulting in three sets of chromosomes (two paternal and one maternal). This abnormal genetic makeup limits the proliferation of trophoblastic cells and therefore results in lower hCG levels compared to complete moles.