Eli is trying to pick out an outfit for the first day of school. He can choose from 6 pairs of pants, t-shirts, 3 sweaters or hoodies, and 4 pairs of shoes. How many different outfits does Eli have to choose from?

To calculate the total number of different outfits Eli can choose from, we multiply the choices for each item.

6 pants * 6 t-shirts * 3 sweaters * 4 shoes = 432 different outfits

Therefore, Eli has 432 different outfits to choose from for the first day of school.