likely not have any significant survival advantage. Sickle cell disease is most commonly found in regions where malaria is prevalent because individuals who are carriers of the sickle cell gene have some level of protection against malaria. In the absence of malaria, the sickle cell gene may not provide any benefit and could potentially be detrimental due to the health complications associated with sickle cell disease. Therefore, the first carrier of the sickle cell gene in a non-malaria region would not have the same adaptive advantage as carriers in malaria-endemic regions.
