Which of the following would describe the difference between the verbs ser and estar?

Which of the following would describe the difference between the verbs ser and estar?

One is used for male and the other female.

They both mean “to be”, but are used for different circumstances.

One is for singular nouns and the other is for plural nouns.

They both mean “to be” and can be used interchangeably.

They both mean “to be”, but are used for different circumstances.