Where is the setting for The big bag theory | The vacation solution

The setting for The Big Bang Theory episode "The Vacation Solution" is split between two locations.

The first location is the main characters' apartment in Pasadena, California. This is where the majority of the scenes with the main characters take place.

The second location is a hotel in Mexico, where Sheldon, Leonard, Howard, and Raj go on a vacation. The episode explores their experience in Mexico, including their interactions with fellow tourists and their attempts to relax and enjoy the vacation.