All of the listed responses contribute to the reduction of gene pools in small populations compared to larger populations. Inbreeding occurs when individuals within a small population mate with close relatives, leading to a decrease in genetic diversity. Bottleneck events refer to situations in which a large portion of a population is drastically reduced in size, often due to natural disasters or human activities. This can result in the loss of many unique genetic traits and a decrease in overall genetic diversity. Lack of suitable mates can lead to limited breeding options, which reduces the chances of introducing new genetic material into the population. Finally, small populations may lack advantageous traits because they have a limited pool of genetic variation from which to draw upon.