The correct response is "respiratory and digestive issues." Cystic fibrosis is a genetic disorder that primarily affects the respiratory and digestive systems. It causes the production of thick, sticky mucus that clogs the lungs and leads to difficulties in breathing and frequent respiratory infections. It also affects the digestive system by blocking the pancreas, leading to nutritional deficiencies and poor growth. Other symptoms of cystic fibrosis may include liver disease, infertility, and nasal polyps.