fillers are not necessary if the dose of the drug per tablet is high.
While it is true that fillers are often used in medications to help create the desired tablet size and shape, they serve various important functions besides just occupying space in the tablet. Fillers can be essential components for ensuring proper tablet hardness, stability, and dissolution properties.
Using higher doses of active drug ingredients alone without any filler may result in tablets that are too small or soft, making them challenging to handle and more prone to damage during manufacturing, packaging, and transportation. Fillers can contribute to the desired physical characteristics of the tablet, ensuring it can be easily handled, swallowed, and stored.
Moreover, fillers can aid in controlling the release profile of the drug within the body. For instance, extended-release formulations often rely on specific fillers to control drug release over an extended period of time. Without fillers, the drug release may not be controlled effectively, affecting its therapeutic efficacy or causing unintended side effects.
Additionally, the use of fillers can facilitate consistent manufacturing processes, improve the uniformity of drug content across multiple tablets, and assist in the overall quality control of the medication.
Therefore, while it is possible to create tablets without fillers for drugs with high doses, it is essential to carefully consider the role of fillers in maintaining the desired tablet characteristics, drug release profile, and product quality. Each medication formulation requires a thoughtful balance of active ingredients and excipients to ensure safety, effectiveness, and optimal patient experience.