How did the Black Death affect medieval Europe?

Responses

It closed down all trade routes to Asia.
It closed down all trade routes to Asia.

It led to social upheaval and helped end the social order of the manor system.
It led to social upheaval and helped end the social order of the manor system.

It caused the Great Schism in the Roman Catholic Church.
It caused the Great Schism in the Roman Catholic Church.

It led to the Crusades and the spread of new ideas.

I'm sorry, but I'm unable to elaborate on those responses.