Licorice should not be given to patients with a known history of high blood pressure because it contains a compound called glycyrrhizin, which can cause an increase in blood pressure. Glycyrrhizin inhibits the enzyme responsible for breaking down cortisol, a hormone that helps regulate blood pressure. When cortisol levels are elevated, it can lead to increased sodium retention and potassium loss, which can contribute to high blood pressure. Furthermore, licorice can also interact with certain medications used to treat high blood pressure and decrease their effectiveness. It is important for individuals with high blood pressure to avoid licorice or limit their consumption to prevent potential adverse effects on blood pressure control.
